Hydralazine, antinuclear antibodies, and the lupus syndrome.
نویسندگان
چکیده
منابع مشابه
Hydralazine antinuclear antibodies and the lupus syndrome.
The incidence of patients with positive antinuclear antibody test results rose during three years of treatment with hydralazine. At the end of that period over half of the patients (both rapid and slow acetylators) had titres exceeding 1/20, but the rate of rise was faster in the slow acetylators than in the rapid. There was a significant relation between the cumulative dose of hydralazine and ...
متن کاملHydralazine Induced Lupus Syndrome Presenting with Recurrent Pericardial Effusion and a Negative Antinuclear Antibody
Drug induced lupus erythematosus (DIL or DILE) is an autoimmune disorder caused by chronic use of certain drugs. We report a unique case of hydralazine induced lupus syndrome (HILS) with a negative antinuclear antibody in a female patient who was on hydralazine for a period of 1.5-2 years and developed recurrent pericardial effusion as a result of it. Initially her condition was managed with a ...
متن کاملAntinuclear antibodies in systemic lupus erythematosus.
Autoantibodies to the three extractable nuclear antigens (ENA), Anti-SSA (Ro), Anti-Sm, Anti-RNP and antinuclear antibodies were determined in 150 patients with SLE. Seventy patients (46.7%) had Anti-SSA (Ro), 40 (26.7%) Anti-Sm and 25 (16.7%) Anti-RNP antibodies. Ninety four percent patients had a positive Fluorescent anti-nuclear antibody (FANA) test. The commonest FANA pattern is the speckle...
متن کاملHydralazine-induced lupus syndrome presenting with large pericardial effusion.
M.A.R. CHAMSI-PASHA, M. BASSIOUNY and E.S.H. KIM From the Department of Cardiovascular Medicine, University of NebraskaMedical Center, Division of Cardiology, 982265 NebraskaMedical Center, Omaha, NE 68198-2265, USA, Department of Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA and Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cl...
متن کاملAntinuclear Antibodies
knowledge of gene regulation, particularly in neoplastic cells, this deficit is striking. With our current understanding of chromosomal translocations, point mutations, and gene amplification in tumor cells, it is surprising to read that there is ". . . no difference between cancer and normal DNA . . ." (p. 130). The author spends a fair amount of time discussing possible mechanisms for the car...
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ژورنال
عنوان ژورنال: BMJ
سال: 1982
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.284.6320.936